Research Progress on Controlling of Crystal Size Distribution (CSD) in Crystallization Process

Abstract Crystallization is an important separation and purification technology for crystal products in chemical industry, which can effectively achieve tailored preparation of some important crystal product quality, such as crystal size distribution (CSD), via crystallization process control. Therefore, the control of CSD during crystallization processes is of great significance for the production of high value-added fine chemicals. Especially in pharmaceutical industry, CSD can have important effects on not only bulk density and dissolution rate of drug products, but also bioavailability. On the basis of the domestic and international research progresses on the topic of CSD control, the methods of CSD control in crystallization was systemically summarized and the QbC (Quality by Control) mode promoted by FDA was then introduced briefly, and finally the process intensification techniques, the application of process control strategies and the trend of CSD control in crystallization processes were highlighted.

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	Wen Ting
	Wang Hairong
	Huang Wei
	Ouyang Jinbo
	Zhang Chuntao

Keywords： crystallization； crystal size distribution (CSD)； process intensification； process control； QbC (Quality by Control) mode

Received 2021-02-22;

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Wen Ting, Wang Hairong, Huang Wei, Ouyang Jinbo, Zhang Chuntao.Research Progress on Controlling of Crystal Size Distribution (CSD) in Crystallization Process[J] Chemcial Industry and Engineering, 2021,V38(4): 44-55

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