Induced Crystallization of Cefotaxime Sodium

Abstract Cefotaxime sodium is easy to gelate during antisolvent crystallization. Aiming at controlling crystallization process and avoiding gelation, different seeds were used to investigate their effects on the anti-solvent crystallization of cefotaxime sodium. The effect of ultrasonic on the crystallization process was also investigated. Crystallization process was monitored using process analytical technologies. The results show that the seeds affect not only the crystal size distribution and crystal shape, but also the crystal purity and yield. The milled seeds can effectively induce nucleation and crystal growth, consume the supersaturation and then avoid gelation. The ultrasonic can induce nucleation as well. The results also shows that specific surface area and surface roughness of the seed crystal are the key factors inducing crystallization of cefotaxime sodium.

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	Articles by authors
	YIN Yong-Heng-1
	BAO Ying-1
	2
	WANG Yong-Li-1
	GAO Zhen-Guo-1
	LIU Dong-3

Keywords： cefotaxime sodium seeds anti-solvent crystallization nucleation ultrasonic

Received 2013-02-21;

Fund:

天津市自然科学基金重点项目(13JCZDJC28400)。

Corresponding Authors: 鲍颖，电话：（022）27405754，E-mail: yingbao@tju.edu.cn。 Email: yingbao@tju.edu.cn

About author: 尹永恒（1989-），男，硕士研究生，主要从事药物结晶技术的研究。

Cite this article:

YIN Yong-Heng, BAO Ying , WANG Yong-Li, GAO Zhen-Guo, LIU Dong.Induced Crystallization of Cefotaxime Sodium[J] Chemcial Industry and Engineering, 2014,V31(2): 48-53