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Chemcial Industry and Engineering 2016, Vol. 33 Issue (3) :31-38    DOI: 10.13353/j.issn.1004.9533.20141086
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Solvent Screening via COSMO-RS Model and Measurement of Solution Thermodynamics for Crystallization of N-(2)-L-Alanyl-L-Glutamine
Chen Yanxin1, Tong Sai1, Zhang Meijing1,2, Xie Chuang1,2, Chen Wei1,2
1. National Engineering Research Center of Industry Crystallization Technology, School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072;
2. Collaborative Innovation Center of Chemical Science and Chemical Engineering(Tianjin), Tianjin 300072, China

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Abstract 

The conductor-like screening model for real solvents (COSMO-RS) was used to predict appropriate solvent for the crystallization process of L-alanyl-L-glutamine in this paper. As a result of the prediction, isopropanol was applied to the process as the optimal solvent which was verified by experiments. The solubility data and solution thermodynamic properties of L-alanyl-L-glutamine were measured from 293.15 K to 318.15 K in the isopropanol-water binary systems. Then the modified Apelblat equation, λh equation, van't Hoff equation and (NIBS) Redlich-Kister equation were used to fit the solubility data. L-alanyl-L-glutamine crystals with improved shape were obtained by the combined cooling with anti-solvent crystallization process in isopropanol-water systems.

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Articles by authors
Chen Yanxin
Tong Sai
Zhang Meijing
Xie Chuang
Chen Wei
KeywordsN-(2)-L-alanyl-L-glutamine;   solubility;   thermodynamic;   crystallization;   COSMO-RS     
Received 2014-04-22;
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Chen Yanxin, Tong Sai, Zhang Meijing, Xie Chuang, Chen Wei.Solvent Screening via COSMO-RS Model and Measurement of Solution Thermodynamics for Crystallization of N-(2)-L-Alanyl-L-Glutamine[J]  Chemcial Industry and Engineering, 2016,V33(3): 31-38
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