The Dual Feed Crystallization Process of Cephradine

化学工业与工程

Chemcial Industry and Engineering

2018, Vol. 35

Issue (3) :43-49 DOI: 10.13353/j.issn.1004.9533.20161127

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The Dual Feed Crystallization Process of Cephradine

Jiang Cuiyuan¹, Wang Ping², Liu Baoshu^1,3, Zhang Junli², Sun Hua^1,3

1. College of Chemical and Pharmaceutical Engineering, Hebei University of Science and Technology, Shijiazhuang 050018, China;
2. NCPC Hebei Huamin Pharmaceutical Co, Ltd, Hebei, 052160, China;
3. Hebei Research Center of Pharmaceutical and Chemical Engineering, Shijiazhuang 050018, China

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Abstract

The dual feed crystallization was used to control the crystallization environment within the crystallization metastable zone, successfully avoid the spontaneous nucleation, the operation was simple and easy to control. The influences of initial concentration, feeding speed, stirring speed, pH scope, quantity of seed crystal and crystal growing time on the yield, crystal habits and crystal size distribution of products were studied using single factor way. The products were obtained with whole crystal habits and homogeneous size distribution at 0.43 g/g initial concentration, 2 mL/min feeding speed, 2.5~2.7 pH scope, 60 min crystal growing time and the quantity of seed crystal was calculated by equation. In addition, with the stirring speed of 70 or 140 r/min, the cluster crystal or clubbed crystal were obtained, respectively. The yield can reached 92%.

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	Jiang Cuiyuan
	Wang Ping
	Liu Baoshu
	Zhang Junli
	Sun Hua

Keywords： cephradine； reactive crystallization； dual feed； yield； crystal habits； crystal size distribution

Received 2016-12-14;

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Jiang Cuiyuan, Wang Ping, Liu Baoshu, Zhang Junli, Sun Hua.The Dual Feed Crystallization Process of Cephradine[J] Chemcial Industry and Engineering, 2018,V35(3): 43-49

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