Preparation of Ibuprofen-Nicotinamide Cocrystal and Its Solubility Measurement
SHEN Zhi-Ming, XIE Chuang, DU Wei, YIN Qiu-Xiang
（National Engineering Research Center of Industrial Crystallization Technology, School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China）
Abstract Large-Scale preparation of ibuprofen-nicotinamide cocrystal was successfully achieved via solution crystallization in ethanolwater mixture with ethanol to water ratio ranging from 1.82 to 7.11. The cocrystal product was verified by PXRD and DSC analyses. In the valid range of ethanol to water volume ratio, the yield of cocrystal reached the maximum of 76.31% at 2.76. To understand this solution cocrystallization process in the solvent mixture, the solubility of ibuprofennicotinamide cocrystal in ethanol-water mixture were measured using gravimetric method from 278 K to 303 K. It was found that the solubility increased monotonically with increasing temperature and increasing ethanol to water volume ratio. Finally the solubility data was correlated using Apelblat equation.
SHEN Zhi-Ming, XIE Chuang, DU Wei, YIN Qiu-Xiang.Preparation of Ibuprofen-Nicotinamide Cocrystal and Its Solubility Measurement[J] Chemcial Industry and Engineering, 2014,V31(1): 38-42
2014, Vol. 31 
