Research on the Spherical Growth Mechanism of Cefixime During the Anti-Solvent Crystallization Process

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Abstract

Spherical products of cefixime were prepared by anti-solvent crystallization and the properties such as bulk density, size distribution and purity of the products were improved by optimizing the process parameters. Considering the instability of the spherical products, in situ sampling method was used to confirm the amorphous nucleation and the crystal morphology of the final spherical products. The assumption of anti-solvent crystallization mechanism for cefixime was proposed and various characterization methods such as X-ray powder diffraction and scanning electron microscope were used to prove that the formation of spherical cefixime crystal is a result of multidirectional growth arising from a central precursor, rather than the aggregation of fine crystals. Finally, the formation of amorphous was inhibited by adding seeds under low degree of supersaturation and as a result, the stability of the spherical products were significantly improved.

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	Articles by authors
	Song Xiaopeng
	Tu Minhai
	Gong Junbo

Keywords： cefixime； anti-solvent crystallization； spherical growth； mechanism

Received 2015-04-30;

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Song Xiaopeng, Tu Minhai, Gong Junbo.Research on the Spherical Growth Mechanism of Cefixime During the Anti-Solvent Crystallization Process[J] Chemcial Industry and Engineering, 2017,V34(6): 57-61

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