The Polymorphy of <em>L</em>-Glutamic Acid under Drop-Microfluidic System

化学工业与工程

Chemcial Industry and Engineering

2018, Vol. 35

Issue (3) :68-73 DOI: 10.13353/j.issn.1004.9533.20161060

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The Polymorphy of L-Glutamic Acid under Drop-Microfluidic System

Jiang Nan, Dang Leping

School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China

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Abstract

The drop-microfluidic method was used to investigate the effect of temperature, droplet size and solvents composition on L-glutamic acid polymorphism. Microscope and powder X-ray diffraction (PXRD) were used to analyze the forms of crystals. The results show that the higher temperature favors the nucleation of metastable crystal form, while lower temperature favors the nucleation of stable crystal form under the same degree of supersaturation. When the degree of supersaturation and the crystallization temperature are same, droplet size has no effect on L-glutamic acid polymorphs. The higher the mole fraction of ethanol in ethanol aqueous solution is, the higher the percentage of metastable crystals is.

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	Jiang Nan
	Dang Leping

Keywords： temperature； polymorph； microfluidics； L-glutamic acid

Received 2016-04-09;

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Jiang Nan, Dang Leping.The Polymorphy of L-Glutamic Acid under Drop-Microfluidic System[J] Chemcial Industry and Engineering, 2018,V35(3): 68-73

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