The Application of Supercritical Fluid-Based Particle Technology as the Platform for Pharmaceutical Preparations Research and Development

Abstract

Preparation of particulate drug delivery systems with some controlled structure is an important and efficious way in the research, development and application of pharmaceuticals. This paper summarized the novel application of supercritical fluid-based particle technology in drug delivery system, including preparation of nano-micron grade drug particles, control of drug polymorphism and formation of composite particles. The characteristics of different types of supercritical fluid technology and the mechanism of particle microstructure regulation were summerized. Based on the principles of thermodynamics and fluid dynamics, supercritical fluid-based particle technology is able to tune and construct the microstructure of active pharmaceutical ingredients, including grain size, crystal habit, polymorph, particle size distribution and so on.

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	Zhu Bin
	Hong Minghuang
	Ren Fuzheng
	Ren Guobin

Keywords： drug delivery system； supercritical fluid-based particle technology； microstructure； nano-micron grade drug particles； drug polymorphism； composite particle

Received 2015-07-10;

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Zhu Bin, Hong Minghuang, Ren Fuzheng, Ren Guobin.The Application of Supercritical Fluid-Based Particle Technology as the Platform for Pharmaceutical Preparations Research and Development[J] Chemcial Industry and Engineering, 2015,V32(5): 52-61

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