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Chemcial Industry and Engineering 2017, Vol. 34 Issue (2) :1-9    DOI: 10.13353/j.issn.1004.9533.20161120
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Application of Process Analytical Tools in Polymorphism of Crystalline Materials
Wang Na1, Tao Xiaolong1, Shi Huanhuan1, Xie Chuang1,2, Yin Qiuxiang1,2, Hao Hongxun1,2
1. National Engineering Research Center of Industrial Crystallization Technology, School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China;
2. Collaborative Innovation Center of Chemical Science and Engineering, Tianjin 300072, China

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Abstract 

Process analytic technology/tools (PAT) are widely used in industrial production and process monitoring with the advantages that the system can be developed, designed, analyzed and controlled through timely measurement of varieties of parameters, with the goal of ensuring final product quality.In view of the wide application of PAT in the field of crystallization, firstly, the working principle of several PAT tools were briefly introduced.The application of Raman (Raman), attenuated total reflection Fourier transformed infrared spectroscopy(ATR-FTIR), focused beam reflectance measurement (FBRM) and particle vision measurement (PVM) in the determination of solubility, the detection of nucleation and the transformation of polymorphic systems were summarized and discussed in detail. The successful application of PAT will promote the further understanding of the mechanism of crystallization process and will help to guide the development, optimization, design and scaling up of the industrial crystallization process.

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Articles by authors
Wang Na
Tao Xiaolong
Shi Huanhuan
Xie Chuang
Yin Qiuxiang
Hao Hongxun
Keywordsprocess analytical tools (PAT);   polymorphism;   solubility;   nucleation;   polymorphic transformation     
Received 2017-01-02;
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Wang Na, Tao Xiaolong, Shi Huanhuan, Xie Chuang, Yin Qiuxiang, Hao Hongxun.Application of Process Analytical Tools in Polymorphism of Crystalline Materials[J]  Chemcial Industry and Engineering, 2017,V34(2): 1-9
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