Progress in the Research of Pharmaceutical Polymorph

Abstract

The study on pharmaceutical polymorphs is a hot topic in the field of drug. Meanwhile, the molecular assembly rules and the controlling methods of pharmaceutical polymorphs are the key contents in the research of polymorphs. In this paper, the nucleation theories, including the classical nucleation theory and two-step nucleation theory, as well as the methods about how to control pharmaceutical polymorph are introduced. In particular, some new strategies for polymorph regulation are highlighted, such as ionic liquid, template agent and microchannel technology. In addition, two practical examples are used to illustrate the important role of phase transformation in improving the quality of pharmaceutical products.

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	Articles by authors
	Zhao Shaolei
	Wang Lingyu
	Wu Songgu

Keywords： pharmaceutical polymorph； nucleation theory； polymorph regulation； phase transformation

Received 2018-03-30;

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Zhao Shaolei, Wang Lingyu, Wu Songgu.Progress in the Research of Pharmaceutical Polymorph[J] Chemcial Industry and Engineering, 2018,V35(3): 12-21

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