Research advances of polymorphism in pharmaceutical cocrystals

Abstract

Pharmaceutical polymorphism is a critical factor that affects the stability and efficacy of the drug. In recent years, a growing number of pharmaceutical cocrystals have been found to be polymorphic and different polymorphs do show different properties. Accordingly, the research of polymorphism in cocrystals is attracting greater attention. In this contribution, the studies which focus on polymorphic cocrystals are reviewed. The concept of polymorphic cocrystals is explained and its different types are identified, including synthon polymorph, packing polymorph, conformational polymorph as well as tautomeric polymorph. The screening methods of polymorphic cocrystals are introduced in detail. Furthermore, the difference in the properties of pharmaceutical cocrystals due to different crystal forms is emphasized.

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	Articles by authors
	Wang Lingyu
	Du Shichao
	Dong Weibing

Keywords： polymorphism； pharmaceutical cocrystal； polymorph screening

Received 2018-04-01;

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Wang Lingyu, Du Shichao, Dong Weibing.Research advances of polymorphism in pharmaceutical cocrystals[J] Chemcial Industry and Engineering, 2018,V35(3): 29-37

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