Integrated DNA storage system for massive digital data

Abstract With the advent of the big data era, the total amount of digital data generated in the world has grown explosively. Due to the natural advantages of extremely high theoretical storage density and long storage time, DNA is considered to provide stable and low-cost storage for massive data. Since the concept was proposed, DNA storage technology has made progress in core aspects such as encoding and decoding algorithms, data recovery and repetitive reading. However, it is still difficult to imagine how the information storage technology based on biomolecular DNA can realize large-scale and stable digital information storage. There is a huge gap between the storage capacity of any reported DNA information storage prototype system and the actual information storage demand. Therefore, in order to realize practical information storage of DNA molecules, in addition to solving the problem of core synthesis cost, there is still a lack of technology for stable preservation and high integration of DNA stored in different files, and when faced with massive data storage, it is necessary to design appropriate indexes for DNA libraries to achieve specific file retrieval, and how to interface with existing electronic systems for DNA biomolecule storage devices. This review focuses on the impact of storage methods on the physical storage density of DNA and file retrieval methods, and introduces the methods of file retrieval and research progress in the development of automated equipment, in order to promote DNA with high physical storage density and convenient file selective retrieval and development of storage systems to facilitate commercial applications of integrated DNA data storage.

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	WEI Yanan
	LIU Qian
	QI Hao

Keywords： DNA information storage data retrieval device integration DNA preservation preservation medium

Received 2022-05-13;

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WEI Yanan, LIU Qian, QI Hao.Integrated DNA storage system for massive digital data[J] Chemcial Industry and Engineering, 2025,V42(1): 173-182

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