Separation and refining method based on sublimation crystallization process

Abstract Sublimation crystallization is a solvent-free crystallization method and it involves a composite process of sublimation and desublimation, which means it has a direct phase transition process of solid-gas-solid. It has great advantages in the separation and refinement of high purity products, the screening of new polymorphs and the preparation of high-quality single crystals. However, there are still great challenges in its theoretical research, industrial amplification, and equipment standardization due to the complex variability of gases. This article summarized sublimation crystallization mechanisms and its applications in polymorph control, co-crystal design, separation and purification of crystal product. Several typical sublimation equipment were introduced. Moreover, some new ideas about deepening the mechanism and perfecting the model are proposed, and the key problems and development directions of sublimation crystallization in the application of efficient separation and precise control of crystallization process are discussed.

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	SU Xin
	SHANG Zeren
	YU Changyou
	GAO Ye
	HE Bingbing
	LI Kangli
	CHEN Mingyang
	GONG Junbo

Keywords： sublimation crystallization desublimation mechanism separation refine sublimation devices

Received 2021-10-16;

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SU Xin, SHANG Zeren, YU Changyou, GAO Ye, HE Bingbing, LI Kangli, CHEN Mingyang, GONG Junbo.Separation and refining method based on sublimation crystallization process[J] Chemcial Industry and Engineering, 2023,V40(5): 40-53

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