The dual feed crystallization process of ceftazidime

化学工业与工程

Chemcial Industry and Engineering

2023, Vol. 40

Issue (1) :90-95 DOI: 10.13353/j.issn.1004.9533.20220821

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The dual feed crystallization process of ceftazidime

WANG Jing¹, SUN Hua¹, YANG Mengde², LIU Baoshu¹

1. College of Chemical and Pharmaceutical Engineering, Hebei University of Science and Technology, Shijiazhuang 050018, China;
2. NCPC Hebei Huamin Pharmaceutical Co., Ltd., Shijiazhuang 052160, China

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Abstract To solve the problems of ceftazidime crystalline product coalescence, crystal habit difference, and uneven particle size distribution, the dual feed crystallization was used to control the crystallization environment within the metastable zone, successfully avoiding the spontaneous nucleation, and the operation was simple and easy to control. The influences of initial concentration, feeding speed, stirring rate, temperature and crystal growing time on the yield, crystal habits and crystal size distribution of products were studied using single factor experimental method. The optimum operation conditions were as follow:at 0.33 g·g^-1 initial concentration, 0.14 mL·min^-1 feeding speed, 27℃, 60 min crystal growing time, stirring rate of 250 r·min^-1,the flake crystal products with whole crystal habits and homogeneous size distribution were obtained, a median particle size of 184 μm and diameter distance of 1.290, and the yield can reach 80%.

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	WANG Jing
	SUN Hua
	YANG Mengde
	LIU Baoshu

Keywords： ceftazidime reactive crystallization dual feed yield crystal habits crystal size distribution

Received 2022-10-25;

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WANG Jing, SUN Hua, YANG Mengde, LIU Baoshu.The dual feed crystallization process of ceftazidime[J] Chemcial Industry and Engineering, 2023,V40(1): 90-95

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