Study on continuous crystallization of cefradine

化学工业与工程

Chemcial Industry and Engineering

2023, Vol. 40

Issue (1) :96-103 DOI: 10.13353/j.issn.1004.9533.20226005

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Study on continuous crystallization of cefradine

XIE Chenxin¹, DU Xue¹, YUAN Mengjie¹, LIU Baoshu¹, YANG Mengde², SUN Hua¹

1. College of Chemical and Pharmaceutical Engineering, Hebei University of Science and Technology, Shijiazhuang 050018, China;
2. NCPC Hebei Huamin Pharmaceutical Co., Ltd., Shijiazhuang 052165, China

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Abstract In this study, a three-stage mixed suspension mixed product discharge crystallizer (MSMPR) was used to conduct the continuous crystallization of cefradine. The effects of a series of crystallization conditions, such as crystallization point, seed addition amount, concentration of raw material liquid, the residence time, crystallization system temperature and stirring rate, on the yield and particle size distribution of cefradine were studied through single factor experiments. The continuous crystallization process parameters of cefradine were optimized. The optimized process parameters were obtained through experiment:the crystallization temperature was 293.15 K, the stirring rate was 180 r·min^-1, the pH of crystallization point was 2.85, the seed addition amount was 3% (mass fraction), the concentration of cefradine liquid was 11% (mass fraction) and the residence time was 33.3 min. The continuous crystal product of cefradine was obtained with average particle size of 85.3 μm and yield of 76.53%.

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	XIE Chenxin
	DU Xue
	YUAN Mengjie
	LIU Baoshu
	YANG Mengde
	SUN Hua

Keywords： cefradine continuous crystallization reactive crystallization process optimization

Received 2022-10-20;

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XIE Chenxin, DU Xue, YUAN Mengjie, LIU Baoshu, YANG Mengde, SUN Hua.Study on continuous crystallization of cefradine[J] Chemcial Industry and Engineering, 2023,V40(1): 96-103

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