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Chemcial Industry and Engineering 2005, Vol. 22 Issue (6) :430-433    DOI:
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Optimization of Fluorination Reaction in the Preparation of Dexamethasone Acetate
ZHU Cui-hong~1,WEN Jian-ping~2,LU Yan-chang~1,WANG Fujun~1(1.Tianjin Tianyao Pharmacuticals Co.,Ltd.,Tianjin 300161,China;2.School of Chemical Engineering,Tianjin University,Tianjin 300072,China)
(1.Tianjin Tianyao Pharmacuticals Co.,Ltd.,Tianjin 300161,China;2.School of Chemical Engineering,Tianjin University,Tianjin 300072,China

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Abstract Fluorination reaction,a key process in the preparation of Dexamethasone acetate,is optimized and the optimum conditions are obtained.The ratio of raw material to HF-DMF is 5.5��1.0,the concentration of HF-DMF is 0.6 g/mL,reaction temperature is(-3 ��)��(-5 ��) and recrystallization solvent is acetone.Under the above optimum reaction conditions,the yields of crude and purified products reach 101.0% and 75.6% respectively.The purity of Dexamethasone acetate is above 98.5%.
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Received 2005-11-15; published 2005-11-15
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ZHU Cui-hong~1,WEN Jian-ping~2,LU Yan-chang~1,WANG Fujun~1.Optimization of Fluorination Reaction in the Preparation of Dexamethasone Acetate[J]  Chemcial Industry and Engineering, 2005,V22(6): 430-433
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