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Chemcial Industry and Engineering 2020, Vol. 37 Issue (4) :40-48    DOI: 10.13353/j.issn.1004.9533.20191925
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Study on Solubility and Crystal Habit of Isoniazid in Various Organic Solvents
Chen Jian, Zhang Yu, Ouyang Jinbo, Han Fangze
School of Chemistry, Biology and Materials Science, East China University of Technology, Nanchang 330013, China

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Abstract The solubility of isoniazid in methanol, ethanol, n-propanol, isopropanol, n-butanol, isobutanol, acetone, acetonitrile, methyl acetate, and butyl acetate, was determined by in-situ turbidity method in the range of 283.15-323.25 K. Data showed that the solubility of isoniazid increased with the increase of temperature. At the same temperature, isoniazid is most soluble in methanol, followed by acetone, ethanol, n-propanol, isopropanol, methyl acetate, isobutanol, n-butanol, acetonitrile, and butyl acetate. Solubility data in all solvents were correlated with the temperature by using the modified Apelblat, Wilson, and NRTL models, and the results were in good agreement with the experimental data. Based on the solubility data, the dissolution thermodynamic properties of isoniazid, including enthalpy of dissolution, entropy of dissolution, Gibbs energy of dissolution, were calculated. The results showed that the dissolution process of isoniazid is endothermic and entropy-increasing. Finally, methanol, ethanol, n-propanol, and acetone, were selected to analyze the influence of solvents on the crystal habit of isoniazid during the cooling crystallization process, and ethanol was determined to be a suitable solvent for the cooling crystallization of isoniazid.
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Chen Jian
Zhang Yu
Ouyang Jinbo
Han Fangze
Keywordssolubility;   isoniazid;   enthalpy of dissolution;   entropy of dissolution;   Gibbs energy of dissolution     
Received 2019-11-04;
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Chen Jian, Zhang Yu, Ouyang Jinbo, Han Fangze.Study on Solubility and Crystal Habit of Isoniazid in Various Organic Solvents[J]  Chemcial Industry and Engineering, 2020,V37(4): 40-48
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