Abstract The solubility,metastable zone and induction period of ciprofloaxicn hydrochloride monohydrate in water or 23% (vol) water\|ethanol solution are measured by laser method.Based on the classic nucleation theory and the induction period theory,a general expression of the relationship between the interface energy and the relative supersolubility is established.Using this expression,the interface energy of ciprofloaxicn hydrochloride monohydrate in solution at various conditions are evaluated in order to supply important parameters for studying on the primary nucleation and crystal growth.
LIU Yong,WANG Jing-kang,YIN Qiu-xiang .Determination the Interfacial Energy of Solid-Ligaid in Ciprofloxacin Hydrochloride Monohydrate Solution[J] Chemcial Industry and Engineering, 2002,V19(5): 354-359
2002, Vol. 19 
