Continuous-flow azo-coupling reaction of C.I. Pigment Red 146 with all inputs are solution

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Abstract The continuous synthetic process of azo pigments satisfies the national strategic needs of producing important basic materials in a green, low-carbon and efficient way. However, the blockage in the pipeline and reactor limits industrial production and application of continuous synthetic process. This work investigates the continuous-flow azo-coupling process of C.I. Pigment Red 146 to evaluate the feasibility of azo pigment continuous synthetic process with all inputs dissolved, in an attempt to tackling the blockage issue. Using polyethylene glycol (PEG) as a hydrotrope, the reagent N-(4-chloro-2,5-dimethoxyphenyl)-3-hydroxy-2-naphthalene amide (Naphthol AS-LC) in water exhibits as a clear solution. The continuous coupling reaction is conducted by addition of strongly acidic diazonium salt and strongly basic Naphthol AS-LC solution into a tubular colliding micromixer, which takes the advantage of faster acid-base neutralization than coupling reaction, so that the continuous coupling process of C.I. Pigment Red 146 can be achieved by the regulation of pH of the reaction mixture via the basicity of Naphthol AS-LC solution. The processing conditions, including pH of reactor outlet, volume fraction of PEG, input flow rate and post-treatment temperature were fully optimized. The azo-coupling reaction yield reaches up to 95.04% by setting the aforementioned parameters as pH=6, 10%, 60 L·h^-1 and 85 ℃, respectively. The color property (ΔE) of the products is less than 1 compared with standard sample, and the particle sizes are significantly smaller than those obtained by batch process. The continuous-flow azo-coupling reaction of C.I. Pigment Red 146 with all inputs dissolved promotes the yield of pigment, reduces energy consumption and more importantly, avoids the blockage, realizing efficient and safe azo-coupling reaction.

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	TONG Liyin
	ZHOU Xueqin
	XU Zhenxiang
	LIU Dongzhi
	LI Wei
	CHEN Yong

Keywords： microreactor microchannels synthesis azo pigments continuous-flow process azo-coupling reaction

Received 2023-03-02;

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TONG Liyin, ZHOU Xueqin, XU Zhenxiang, LIU Dongzhi, LI Wei, CHEN Yong.Continuous-flow azo-coupling reaction of C.I. Pigment Red 146 with all inputs are solution[J] Chemcial Industry and Engineering, 2024,V41(6): 34-41

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