Optimization of synthesis of trimethylolpropane catalyzed by [Bmmim]OH by Box-Behnken method

化学工业与工程

Chemcial Industry and Engineering

2024, Vol. 41

Issue (6) :26-33 DOI: 10.13353/j.issn.1004.9533.20230139

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Optimization of synthesis of trimethylolpropane catalyzed by [Bmmim]OH by Box-Behnken method

SU Qiyi¹, XIE Tian^1,2,3,4, QUAN Hongdong^2,3, YANG Xiuguo^2,3, LI Hongyan^2,3

1. School of Chemistry and Chemical Engineering, Guizhou University, Guiyang 550025, China;
2. Chifeng Ruiyang Chemical Co., Ltd., Chifeng, Inner Mongolia 024076, China;
3. Key Laboratory of Polyol Chemical New Materials Enterprises of Inner Mongolia Autonomous Region, Chifeng, Inner Mongolia 024076, China;
4. National Key Laboratory for Efficient and Comprehensive Utilization of Medium and Low Grade Phosphate Rock and Its Associated Resources, Guiyang 550016, China

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Abstract [Bmmim] OH was synthesized by reacting [Bmmim] Br and KOH in methanol for 24 h and purified with a yield of 87.39%. Trimethylolpropane was synthesized using the synthesized [Bmmim]OH as catalyst and formaldehyde and butanal as substrates. Based on the single factor experiments, the effects of Cannizzaro reaction time, molar ratio of HCHO to CH₃CH₂CH₂CHO, and CH₃CH₂CH₂CHO drop acceleration on the product concentration of trimethylolpropane were investigated. A Box-Behnken response surface method is used to establish a mathematical model by taking the product concentration of trimethylolpropane as the response value. The order of interaction among the three was: molar ratio of formaldehyde and butanal > CH₃CH₂CH₂CHO drop acceleration > Cannizzaro reaction time. The optimal process conditions were as follows: the molar ratio of formaldehyde to butanal was 3.074, the Cannizzaro reaction time was 37.21 min, and the drop acceleration was 10.45 r·min^-1. The deviation between the experimental value and the predicted value is 2.65%, indicating a good fit.

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	SU Qiyi
	XIE Tian
	QUAN Hongdong
	YANG Xiuguo
	LI Hongyan

Keywords： [Bmmim]OH ionic liquid trimethylolpropane response surface method

Received 2023-03-15;

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SU Qiyi, XIE Tian, QUAN Hongdong, YANG Xiuguo, LI Hongyan.Optimization of synthesis of trimethylolpropane catalyzed by [Bmmim]OH by Box-Behnken method[J] Chemcial Industry and Engineering, 2024,V41(6): 26-33

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