Continuous-flow synthesis process of C.I. Pigment Red 146

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Abstract With 3-amino-4-methoxybenzanilide(Red base KD) as diazonium component, N-(4-chloro-2,5-dimethoxyphenyl)-3-hydroxy-2-naphthalene amide(Naphthol AS-LC) as azo-coupling component, the tubular micromixer was applied to carry out diazotization and azo-coupling reaction, respectively, for the continuous-flow synthesis process of Pigment Red 146. The temperature, the amount of hydrochloric acid of diazotization and the temperature, pH of azo-coupling reaction were optimized. As a result, continuous-flow synthesis process was carried out at 20 ℃, n(HCl)∶n(Red base KD)=2.5∶1.0, the yield of pigment reached 97.0%, color property ΔE<1, and particle size was significantly smaller than that of the batch process. Compared with batch process, continuous process not only increases the yield of pigment, but also reduces the energy consumption and material cost, improves production efficiency, so it has broad prospect for industrialization.

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	Articles by authors
	WANG Xudong
	ZHOU Xueqin
	TONG Liyin
	LIU Dongzhi
	LI Wei

Keywords： Pigment Red 146 micromixer continuous-flow process diazotization azo-coupling reaction

Received 2021-04-03;

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WANG Xudong, ZHOU Xueqin, TONG Liyin, LIU Dongzhi, LI Wei.Continuous-flow synthesis process of C.I. Pigment Red 146[J] Chemcial Industry and Engineering, 2022,V39(4): 1-8

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