化学工业与工程
Home  |   |  About Journal  |  Editorial Board  |  Instruction  |  Subscriptions  |  Download  |  Publication Ethics  |  Contacts Us  |  Chinese
Chemcial Industry and Engineering 2023, Vol. 40 Issue (1) :25-40    DOI: 10.13353/j.issn.1004.9533.20220829
Current Issue | Next Issue | Archive | Adv Search << | >>
Regulation of pathological biomineralization processes by molecular additive and modified material surface
LI Zhonghua1, MENG Yingshuang1, ZHOU Cheng2, CHANG Pei2, JIANG Hanyu2, JIANG Xiaobin1
1. School of Chemical Engineering, Dalian University of Technology, State Key Laboratory of Fine Chemicals, Liaoning Dalian 116024, China;
2. Xi'an Modern Chemistry Research Institute, Xi'an 710065, China

Abstract
Reference
Related Articles
Download: PDF (6579KB)   HTML ()   Export: BibTeX or EndNote (RIS)      Supporting Info
Guide  
Abstract Minerals crystallization in body fluids and adhering to the surface of human tissues, causing inflammation, urinary calculi, blockage of the vessel, and damage to many physiological function when the biological environment deviates from normal or macromolecules fail to regulate the mineralization process. Thus, it is important to improve medical implantation anti-fouling and anti-scaling ability. To solve the above problems, it is urged to improve the thermodynamic and interface engineering of crystallization, which has outstanding interdisciplinary characteristics in the fields of chemical engineering, materials science and medicine. This paper starts with two strategies:change the environment of body fluids and design the surface of medical implant materials. Mechanisms of pathological mineralization are described. Crystallization regulation methods are then reviewed. Small molecules, macromolecules, nanoparticles, and polymer surfaces capable of inhibiting pathological mineralization are highlighted, and strategies for design effective inhibitors and mechanisms of inhibition of crystallization are discussed. The main problems in the inhibiting pathological mineralization are summarized, and the prospects on the development of inhibitor molecules and the design of antifouling surface are put forward.
Service
Email this article
Add to my bookshelf
Add to citation manager
Email Alert
RSS
Articles by authors
LI Zhonghua
MENG Yingshuang
ZHOU Cheng
CHANG Pei
JIANG Hanyu
JIANG Xiaobin
Keywordscrystallization regulation   abnormal mineralization   material’s interface   nanoparticle   molecular additives     
Received 2022-11-02;
Fund
About author:
Cite this article:   
LI Zhonghua, MENG Yingshuang, ZHOU Cheng, CHANG Pei, JIANG Hanyu, JIANG Xiaobin.Regulation of pathological biomineralization processes by molecular additive and modified material surface[J]  Chemcial Industry and Engineering, 2023,V40(1): 25-40
Copyright 2010 by Chemcial Industry and Engineering