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Chemcial Industry and Engineering 2015, Vol. 32 Issue (6) :31-35    DOI: 10.13353/j.issn.1004.9533.20131143
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Synthesis and Properties of Chitosan-g-Terminal Carboxyl Group-Poly(amidoamine)
Zhang Xiaoyang, Zhao Jun, Yao Fanglian
School of Chemical Engineering and Technology, Key Laboratory of Systems Bioengineering of Ministry of Education, Tianjin University, Tianjin 300072, China

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Abstract 

Terminal carboxyl group-poly(amidoamine) (PAMAM) was synthesized by the Michael addition reaction of methyl acrylate and ethylenediamine,followed by the hydrolysis of terminal ester groups to carboxyl group. Chitosan-grafted-terminal carboxyl groups poly(amidoamine)(CS-g-PAMAM) was prepared via amidation reaction of chitosan and terminal carboxyl group-PAMAM in the presence of EDC/NHS. The resultant products were characterized by nuclear magnetic resonance spectroscopy and thermogravimetric analysis respectively. The optimal feeding ratio was determined by the study about the water-solubility and size of the resultant CS-g-PAMAM nanopartilces. The morphology of CS-g-PAMAM in water was observed by TEM and a formation mechanism of CS-g-PAMAM core-shell nanoparticles was proposed.

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Zhang Xiaoyang
Zhao Jun
Yao Fanglian
Keywordschitosan;   terminal carboxyl group-poly(amidoamine);   self-assembly;   core-shell nanoparticles     
Received 2013-05-22;
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Zhang Xiaoyang, Zhao Jun, Yao Fanglian.Synthesis and Properties of Chitosan-g-Terminal Carboxyl Group-Poly(amidoamine)[J]  Chemcial Industry and Engineering, 2015,V32(6): 31-35
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