A New Method for the Synthesis of 2, 3, 4-Trihydroxybenzophenone

化学工业与工程

Chemcial Industry and Engineering

2019, Vol. 36

Issue (6) :17-22 DOI: 10.13353/j.issn.1004.9533.20191001

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A New Method for the Synthesis of 2, 3, 4-Trihydroxybenzophenone

Liu Lanxiang¹, Yi Guandong¹, Zhang Wenwen¹, Li Kun¹, Ji Haobo¹, Chen Chiqing², Liu Yiwen², Zhang Hong¹

1. Research Center of Engineering and Technology of Characteristic Forest Resources, National Forestry and Grassland Administration, Kunming 650224, China;
2. Wufeng Chicheng Biotechnology Co., LTD., Research Center of Engineering and Technology on Efficient Cultivation and Intensive Processing for Gallnut, National Forestry and Grassland Administration, Hubei Wufeng 443400, China

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Abstract The important industrial material 2,3,4-trihydroxydiphenyl (3HBP) was synthesized from pyrogallic acid and benzotrichloride, oxalate and phosphoric acid as the catalyst, methanol-water as mixed solvents in the nitrogen atmosphere. The results of single factor experiments show that the optimum process conditions for synthesis of 3HBP are:Pyrobitumen gallic acid is 6.3 g (0.05 mol), the methanol-water mixed solvents (volume ratio 2:8) is 50.0 mL, benzotrichloride (0.055 mol) is added slowly when the mixture solution is 40℃, and then the temperature of the mixture solution is kept at 65℃ until the pyrogallic acid disappear. The yield of 3HBP was 89.1% tested by column chromatography. The method was simple, environmentally friendly and had value potential of industrial application.

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	Liu Lanxiang
	Yi Guandong
	Zhang Wenwen
	Li Kun
	Ji Haobo
	Chen Chiqing
	Liu Yiwen
	Zhang Hong

Keywords： 2, 3, 4-trihydroxydiphenyl； synthesis； optimum process

Received 2019-01-10;

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Liu Lanxiang, Yi Guandong, Zhang Wenwen, Li Kun, Ji Haobo, Chen Chiqing, Liu Yiwen, Zhang Hong.A New Method for the Synthesis of 2, 3, 4-Trihydroxybenzophenone[J] Chemcial Industry and Engineering, 2019,V36(6): 17-22

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