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Chemcial Industry and Engineering 2018, Vol. 35 Issue (5) :7-11    DOI: 10.13353/j.issn.1004.9533.20161097
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Synthesis of 2, 5-Dichloro-N-[2-(Isopropylsulfonyl) Phenyl]-Pyrimidin-4-Amine
Chen Yalin1,2,3, Li Wei1,2,3, Zhou Xueqin1,2,3, Wang Tianyang1,2,3, Liu Dongzhi1,2,3
1. School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China;
2. Collaborative Innovation Center of Chemical Science and Engineering, Tianjin 300072, China;
3. Tianjin Engineering Research Center of Functional Fine Chemicals, Tianjin 300072, China

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Abstract 2,5-Dichloro-N-(2-(isopropylsulfonyl) phenyl)-pyrimidin-4-amine was synthesized from 1-(isopropylsulfonyl)-2-nitrobenzene by reaction of reduction and nucleophilic substitution. The target compounds with high purity and high yield were obtained by optimizing the reaction conditions. The structure of the resulting product was confirmed by 1H-NMR and MS. The process exhibited short reaction time, low cost, high yield, and to a certain extent, in line with the requirements of industrial production.
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Chen Yalin
Li Wei
Zhou Xueqin
Wang Tianyang
Liu Dongzhi
Keywords2,5-dichloro-N-[2-(isopropylsulfonyl) phenyl]-pyrimidin-4-amine;   anaplastic lymphoma kinase;   2-(isopropylsulfonyl) benzenamine;   synthesis     
Received 2016-05-10;
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Chen Yalin, Li Wei, Zhou Xueqin, Wang Tianyang, Liu Dongzhi.Synthesis of 2, 5-Dichloro-N-[2-(Isopropylsulfonyl) Phenyl]-Pyrimidin-4-Amine[J]  Chemcial Industry and Engineering, 2018,V35(5): 7-11
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