Kinetics of semi-batch reaction crystallization of methionine under CO<sub>2</sub> acidification condition

Abstract Aiming at the synthesis of methionine by hydantion method, using potassium methionine as raw material, the reaction crystallization process of methionine under CO₂ acidification condition was studied by batch-dynamic method, and the crystallization kinetic model was established. The population number balance equation was solved by moment method, and the crystallization kinetic parameters were obtained by fitting the data with multiple linear regression using least square method. The results show that the crystal growth is size-independent, and growth activation energy is 21.0 kJ·mol^-1. The exponents of supersaturation with respect to nucleation rate and growth rate are 0.62 and 1.52, respectively. The effect of crystal agglomeration on the crystallization process cannot be ignored. The apparent gas velocity and stirring speed have obvious effects on crystal nucleation and agglomeration. High supersaturation and high stirring speed are not conducive to the increase of average crystal size.

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	CHEN Zhirong
	ZHANG Fujia
	YUAN Shenfeng
	YIN Hong

Keywords： methionine reaction crystallization batch-dynamic method crystallization kinetics

Received 2022-06-15;

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CHEN Zhirong, ZHANG Fujia, YUAN Shenfeng, YIN Hong.Kinetics of semi-batch reaction crystallization of methionine under CO₂ acidification condition[J] Chemcial Industry and Engineering, 2023,V40(4): 58-66

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