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Chemcial Industry and Engineering 2023, Vol. 40 Issue (5) :144-150    DOI: 10.13353/j.issn.1004.9533.20230137
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Targeted polymeric nanoparticles for enhanced antitumor efficacy of polyoxometalates
WAN Dong, ZHANG Yuying, WANG Huan, YAO Tianzi, GUO Jianhui, LIU Yujun, ZHANG Saihui, PAN Jie
School of Chemistry and Chemical Engineering, Tiangong University, Tianjin 300387, China

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Abstract Polyoxometalates (POMs) works as a promising agent in medicine. They are exploited for anticancer, antibacterial, and so on. But they have poor water solubility and nonspecific interactions with normal cells, resulting in toxicity side effects on liver and kidney, all of which limit their practical application for antitumor in clinic. Polymeric nanoparticles (NPs) modified with targeting molecule can solve these problems of POMs. Herein, novel polymeric NPs (PLA-mPEG1000/TPGS3350-Folate) encapsulating POMs were developed for targeted delivery of POMs to tumor cells. In comparison with NPs without targeting function, these NPs decorated with folate (FOL) illustrated high antitumor activity to MCF-7 melanoma cells in vitro, which is perhaps due to enhanced cellular take through folate receptor-mediated endocytosis pathway. As a result, it is supposed that these NPs designed in this work have enormous potential for the treatment of cancer in the future.
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Articles by authors
WAN Dong
ZHANG Yuying
WANG Huan
YAO Tianzi
GUO Jianhui
LIU Yujun
ZHANG Saihui
PAN Jie
Keywordspolyoxometalates   cancer   nanoparticles   target   folate     
Received 2023-03-14;
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WAN Dong, ZHANG Yuying, WANG Huan, YAO Tianzi, GUO Jianhui, LIU Yujun, ZHANG Saihui, PAN Jie.Targeted polymeric nanoparticles for enhanced antitumor efficacy of polyoxometalates[J]  Chemcial Industry and Engineering, 2023,V40(5): 144-150
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