Highly selective synthesis of <em>m</em>-trifluoromethyl acetophenone by catalytic acylation based on solid acid catalyst

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Abstract m-Trifluoromethyl acetophenone(TFAP) is a key intermediate in the synthesis of trifloxystrobin, and also an important raw material for the synthesis of other chemicals such as pharmaceuticals and dyes. Most of the synthesis routes that have been reported presently suffer from complex processes, high environmental pollution and high risk. In this paper, we investigated the Friedel-Crafts acylation reaction for preparation of m-trifluoromethyl acetophenone from trifluorotoluene with acetyl chloride as the acylating agent in one step based on the loaded solid acid catalyst, which focused on the effects of catalyst loading, reaction temperature and reaction solvent on the catalytic preparation of trifluoromethy lacetophenone. The optimal process conditions were determined for the reflux reaction at 50 ℃ with FeCl₃ as the active component, γ-Al₂O₃ as the carrier, dichloroethane as the solvent, and the catalyst addition of 10%. The selectivity of the target product trifluoromethyl acetophenone could reach 99%, and the one-way conversion of trifluorotoluene was 15.5%. The prepared FeCl₃/γ-Al₂O₃ loaded solid acids were characterized by XPS, BET and NH₃-TPD, and the possible catalytic reaction mechanism was proposed. The synthetic method is easy to operate, with low cost catalyst and environmentally friendly post-treatment process, which exhibiting good potential for industrial application.

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	LI Bin
	WANG Wenjun
	JIANG Shuang
	ZHANG Tianyong

Keywords： solid acid catalysis Friedel-Crafts acylation reaction m-trifluoromethyl acetophenone trifluoromethyl benzene high selectivity

Received 2023-04-28;

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LI Bin, WANG Wenjun, JIANG Shuang, ZHANG Tianyong.Highly selective synthesis of m-trifluoromethyl acetophenone by catalytic acylation based on solid acid catalyst[J] Chemcial Industry and Engineering, 2025,V42(2): 20-27

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