Synthesis and properties of novel fluoroboron nanoparticle fluorescent probes

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Abstract In order to solve the problem of short absorption wavelength, poor water solubility and poor biocompatibility of Fluoroboron-fluorescent dyes (BODIPY) in tumor diagnosis, two BODIPY molecules with absorption wavelengths reaching the near-infrared region have been designed and synthesized, and they have been combined with DSPE-PEG2000-MAL-RGD (PC-RGD) to form nanoparticles with good water solubility and biocompatibility. Then the fluorescence imaging ability of nanoparticles was studied. The results showed that the fluorescence emission wavelengths of the mono-substituted molecule 3a and the di-substituted molecule 3b reached 650 and 775 nm, respectively. And di-substituted molecule 3b shows greater Stokes shift than 3a due to its higher degree of conjugation. Moreover, the encapsulated nanoparticles show good water solubility and biocompatibility, which provides a possibility as fluorescent probes for tumor diagnosis.

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	YIN Juanjuan
	FENG Tong
	XUE Zhongbo
	FENG Yaqing
	MENG Shuxian

Keywords： fluoroboron-fluorescent dyes (BODIPY)； nanoparticles； fluorescent probe； tumor diagnosis； liposome

Received 2021-02-24;

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YIN Juanjuan, FENG Tong, XUE Zhongbo, FENG Yaqing, MENG Shuxian.Synthesis and properties of novel fluoroboron nanoparticle fluorescent probes[J] Chemcial Industry and Engineering, 2022,V39(1): 19-26

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