Preparation and characterization of dual-antibiotic-loaded hydrophilic polyurethane foam

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Abstract Chronic wounds caused by bacteria, foreign bodies, inflammation and other factors will have excessive wound exudate outflow, damaging the surrounding healthy skin, which is not conducive to wound healing. To solve the above problems, we prepared polyurethane foam containing hydrophilic and hydrophobic drugs as a wound dressing for chronic wounds. The pore size of the foam was uniform and distributed between 200—400 μm observed by SEM. The loading drugs had a slight effect on the mechanical properties of polyurethane foam and had little effect on the liquid absorption rate and water retention rate. The hydrophilic drug could be released rapidly, and hydrophobic drug could be released continuously. The drug-loaded polyurethane foam showed excellent antibacterial activity against gram-negative E. coli and gram-positive S. aureus. Meanwhile, polyurethane foams had excellent biocompatibility. Therefore, the multifunctional polyurethane foams are suitable as a candidate material for chronic wound dressing.

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	Articles by authors
	GAO Shangdong
	CHEN Shangliang
	LI Shuangyang
	YE Zhanpeng
	DENG Liandong
	DONG Anjie

Keywords： polyurethane foam； drug release； antibacterial； dressing

Received 2021-01-11;

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GAO Shangdong, CHEN Shangliang, LI Shuangyang, YE Zhanpeng, DENG Liandong, DONG Anjie.Preparation and characterization of dual-antibiotic-loaded hydrophilic polyurethane foam[J] Chemcial Industry and Engineering, 2022,V39(1): 11-18

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