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Chemcial Industry and Engineering 2023, Vol. 40 Issue (1) :41-52    DOI: 10.13353/j.issn.1004.9533.20223013
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Recent advances of melt crystallization in pharmaceutical polymorphism
LI Shuting, LI Ao, LIU Binbin, LU Ming
School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China

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Abstract Here we reviewed recent advances of melt crystallization in pharmaceutical polymorphism, including routine melt crystallization, polymer-assistant crystallization, nanoconfinement crystallization and melt microdroplet strategy for single-crystal cultivation. This work aims to promote the research in drug polymorphism and solid-state chemistry.
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LI Shuting
LI Ao
LIU Binbin
LU Ming
Keywordsmelt crystallization   pharmaceutical polymorphism   polymer-assistant crystallization   nanoconfinement crystallization   melt microdroplet strategy for single-crystal cultivation     
Received 2022-12-07;
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LI Shuting, LI Ao, LIU Binbin, LU Ming.Recent advances of melt crystallization in pharmaceutical polymorphism[J]  Chemcial Industry and Engineering, 2023,V40(1): 41-52
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