Preparation and Characterization of Photocrosslinked PVA-SBQ/GMHA Composite Nanofibers

化学工业与工程

Chemcial Industry and Engineering

2021, Vol. 38

Issue (1) :53-60 DOI: 10.13353/j.issn.1004.9533.20200113

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Preparation and Characterization of Photocrosslinked PVA-SBQ/GMHA Composite Nanofibers

Song Xiaoyan¹, Yang Zhe¹, Xu Rumeng¹, Xing Jinfeng²

1. College of Material Science and Engineering, Tiangong University, Tianjin 300387, China;
2. School of Chemical Engineering and Technology, Tianjin University, Tianjin 300350, China

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Abstract In order to enhance the water solubility of hyaluronic acid and achieve sustained drug release, this study used electrospinning technology to prepare composite nanofiber membranes of modified hyaluronic acid (GMHA) and polyvinyl alcohol-styrene pyridine (PVA-SBQ). Then the photocrosslinked PVA-SBQ/GMHA composite fibers were obtained under ultraviolet irradiation. The morphology of PVA-SBQ/GMHA nanofibers was analyzed by scanning electron microscopy. The swelling ratio and drug release performance of composite nanofibers under different ultraviolet illumination time, temperature and pH were studied systematically, which indicated that composite nanofiber membranes swelled with the increase of temperature become smaller and the degree of swelling at pH 2.2 is less than that at pH 7.2. The cumulative release rate of 1.0% drug-loaded PVA-SBQ/GMHA fiber membrane after photocrosslinking was about 40% within 10 h, and the cumulative release curve was relatively flat, which achieved the purpose of drug sustained release.

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	Song Xiaoyan
	Yang Zhe
	Xu Rumeng
	Xing Jinfeng

Keywords： drug release； polyvinyl alcohol-styrene pyridine(PVA-SBQ)； modified hyaluronic acid(GMHA)； electrospinning； UV crosslinking

Received 2020-02-21;

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Song Xiaoyan, Yang Zhe, Xu Rumeng, Xing Jinfeng.Preparation and Characterization of Photocrosslinked PVA-SBQ/GMHA Composite Nanofibers[J] Chemcial Industry and Engineering, 2021,V38(1): 53-60

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