Studies on Electrospun SF/PLGA Fibrous Scaffolds for Vascular Tissue Engineering

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Abstract

Silk fibroin (SF) and lactic acid/glycolic acid copolymer (PLGA) were dissolved in 1,1,1,3,3,3-hexafluoroisopropanol to prepare SF/PLGA solution, and the electrospinning technique was used to prepare the SF/PLGA nanofibrous scaffolds. The scaffolds were characterized by SEM, and process influences on nanofiber morphology such as solution concentration, spinning voltage, receiving distance and volume flow rate were investigated in order to get the optimum process parameters of electrospinning. We tested the HUVECs cells compatibility of the nanofibrous scaffolds. The results showed that the SF/PLGA scaffolds could enhance the viability, spreading, and attachment of HUVECs, so these scaffolds have a good application prospect in the field of tissue engineering.

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	Articles by authors
	Zhou Wei
	Feng Yakai

Keywords： silk fibroin； PLGA； electrospinning； fibrous scaffold； tissue engineering

Received 2014-05-09;

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Cite this article:

Zhou Wei, Feng Yakai.Studies on Electrospun SF/PLGA Fibrous Scaffolds for Vascular Tissue Engineering[J] Chemcial Industry and Engineering, 2016,V33(5): 56-61

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