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Chemcial Industry and Engineering 2022, Vol. 39 Issue (1) :66-74    DOI: 10.13353/j.issn.1004.9533.20210103
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Investigation on the oiling out crystallization of raspberry ketone
WEI Jian, ZHU Liang, SHA Zuoliang, WANG Yanfei, YANG Libin
College of Chemical Engineering and Materials Science of Tianjin University of Science and Technology, Tianjin 300450, China

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Abstract Experimental results indicated that the oiling out phenomenon generally occurred during the cooling crystallization of raspberry ketone in the mixed solvent of n-propanol-water, and the occurrence of oiling out phenomenon will affect the quality of the final crystal product. In order to suppress the occurrence of oiling out phenomenon in the cooling crystallization process of raspberry ketone, a systematic investigation on this phenomenon had been carried out. Firstly, FBRM was used to determine the thermodynamic data of raspberry ketone in n-propanol-water mixed solvent. The oiling out curve, clarification curve, solubility curve and supersolubility curve were experimentally determined, and the oiling out metastable zone was established. Subsequently, the metastable phase diagram of oiling out crystallization was measured. Combined with the metastable phase diagram of oiling out crystallization of raspberry ketone, the key factors that have the influence on the oiling out behavior of raspberry ketone and the effective methods to inhibit the oiling out behavior were investigated. Experimental results have shown that the initial concentration of the solution, cooling rate and stirring rate are the crucial factors for the generation of oiling out during the cooling crystallization process of raspberry ketone. In addition, the effects of seed addition strategies on the inhibition of oiling out behavior of raspberry ketone were investigated, and the optimized crystallization process of raspberry ketone that can avoid the oiling out was established.
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WEI Jian
ZHU Liang
SHA Zuoliang
WANG Yanfei
YANG Libin
Keywordscrystallization of raspberry ketone;   thermodynamics of oiling out crystallization;   inhibition of oiling out;   cooling crystallization;   phase equilibrium     
Received 2021-01-05;
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WEI Jian, ZHU Liang, SHA Zuoliang, WANG Yanfei, YANG Libin.Investigation on the oiling out crystallization of raspberry ketone[J]  Chemcial Industry and Engineering, 2022,V39(1): 66-74
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