Abstract In this paper,various synthesizing method,medical mechanism,productive situation at home and abroad of amlodipine are reviewed.The key step in the synthesis of amlodipine,cyclization of the 1,4-dihydropyridine by Michael addition reaction and Hantzsch reaction in which different amine protective groups were used,are illustrated in details.By comparing the advantages and disadvantages of the two different processes,the feasibilities of industrial application is discussed.
2006, Vol. 23 
