Preparation and Content Analysis of Metformin Microemulsion

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Abstract Based on the obtained pseudo-ternary phase diagrams,the effects of surfactants,cosurfactants and oils on the microemulsion were studied and the formulations were optimized.From the formulation the stable metformin loaded water-in-oil microemulsion could be prepared using teaoil/Tween 80-Span85/PEG400/water system.The mean diameter of the microemulsions determined by the Photon Correlation Spectroscopy was 46.3 nm with Gauss distribution.The content of metformin loaded in microemulsions was analyzed by UV method.The average recovery by UV method was 99.56% with standard deviation of 1.23%.The metformin microemulsion prepared was pharmaceutically acceptable and the method to determine the concentration of metformin was acute and reliable.

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Received 2007-11-15; published 2007-11-15

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XU Zhi-bin~1,LIU Ming-yan~1,JIANG Rong-gao~2,WANG Chun-long~2,LIU Zheng-jun~1.Preparation and Content Analysis of Metformin Microemulsion[J] Chemcial Industry and Engineering, 2007,V24(6): 505-509

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