Progress of Anti-Cancer Drug of Discodermolide

Abstract Discodermolide a multiple-hydroxyl-��-lactone compound,is isolated from marine sponge discodermia dissolute.Similar to paclitaxel,discodermolide is also a microtubule-stabilizing agent and shares an overlapping ��tubulin binding site with paclitaxel.However,discodermolide is better water-resolvable and more potent than paclitaxel,and it is also active in taxol-resistant cell lines.So discodermolide is determined to be a potential anticancer-drug and attracts many researchers' attention.Based on the references in recent years,the mechanism of action,synthesis,biological activity,modeling study and the application prospect of discodermolide are reviewed in this paper.

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Received 2009-03-15; published 2009-03-15

Cite this article:

LI Jie~1,SHA Yong-juan~2,LI Yan-ni~3.Progress of Anti-Cancer Drug of Discodermolide[J] Chemcial Industry and Engineering, 2009,V26(2): 169-175

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