Development of Starburst PAMAM Dendrimers as Gene Vector

化学工业与工程

Chemcial Industry and Engineering

2009, Vol. 26

Issue (2) :165-168 DOI:

Article

Current Issue | Next Issue | Archive | Adv Search

<< | >>

Development of Starburst PAMAM Dendrimers as Gene Vector

ZHANG Wei,SHI Qing-hong(School of Chemical Engineering and Technology,Tianjin University,Tianjin 300072,China)

(School of Chemical Engineering and Technology,Tianjin University,Tianjin 300072,China

Abstract	Reference	Related Articles

Download: PDF (163KB) HTML 1KB Export: BibTeX or EndNote (RIS) Supporting Info

Abstract In recent years,the new nonviral vectors especially starburst PAMAM(poly amidoamine)dendrimers,have been widely applied in the gene therapy.As for its low cytotoxicity and special structure,it becomes the key point of study.This article focus on the characteristics of structure,capability,system of gene transfer and the recent development of PAMAM dendrimers as well as its application in vectors.

	Service

	Email this article
	Add to my bookshelf
	Add to citation manager
	Email Alert
	RSS
	Articles by authors

Keywords��

Received 2009-03-15; published 2009-03-15

Cite this article:

ZHANG Wei,SHI Qing-hong.Development of Starburst PAMAM Dendrimers as Gene Vector[J] Chemcial Industry and Engineering, 2009,V26(2): 165-168

[1]	GLOVER D J,LIPPS H J,JANS D A,et al.Non-viraltherapeutic gene expression in humans[J].Nature ReviewGenetics.2005,6(8):299-311
[2]	CALVO M C,THRASHER A,MAVILIO F.The future ofgene therapy[J].Nature.2004,427:779-781
[3]	��.��Ƶ��о��չ[J].��ҽѧ��ٴ�,2002,22(6):504-507.
[4]	��,��Ӣ��.�ǲ��򴫵�ϵͳ��о��չ[J].��ҽѧ��ѧԺ��,2003,27(5):384-387.
[5]	�˽��,��ѧ��.��[M].��:��ѧ��,2001.
[6]	TOMALIA D A,BAKER H,DEWALD J.A new class ofpolymers:Starburst-dendritic macromolecules[J].JPolymer,1985,17(1):117-132.
[7]	LOTHIAN M K.A contemporary survey of covalentconnectivity and complexity.The divergent synthesis of poly(thioether)dendrimers.Amplified,genealogically directedsynthesis leading to the de Gennes Gennes dense packedstate[J].Tetrahedron,1997,53:15 495-15 513.
[8]	EICHMAN J D,BIELINSKA A U.The use of PAMAMdendrimers in the efficient transfer of genetic material intocells[J].Pharmaceutical Science&Technology Today.2000,3(7):232-245
[9]	DURAIRAJ C.The development of folate-PAMAMdendrimer conjugates for targeted delivery of anti-arthriticdrugs and their pharmacokinetics and biodistribution inarthritic rats[J].Biomaterials.2007,28:504-512
[10]	MINGLU M,YIYUN C.Evaluation of polyamidoamine(PAMAM)dendrimers as drug carriers of anti-bacterialdrugs using sulfamethoxazole(SMZ)as a model drug[J].European Journal of Medicinal Chemistry.2007,42:93-98
[11]	KIM T,BAEK J.Synthesis and characterization of a novelarginine-grafted dendritic block copolymer for gene deliveryand study of its cellular uptake pathway leading totransfection[J].Bioconjugate Chem.2007,18:309-317
[12]	JEVPRASESPHANT R,PENNY J,JALAL R,et al.Theinfluence of surface modification on the cytotoxicity ofPAMAM dendrimers[J].Int J Pharm.2003,252(1/2):263-266
[13]	ZHOU L,GAN L,LI H,et al.Studies on the interactionsbetween DNA and PAMAM with fluorescent probe[Ru(phen)2dppz]2+[J].Pharmaceutic Biomedic Analys.2007,43:330-334
[14]	HUANG R Q.Efficient gene delivery targeted to the brainusing a transferrin-conjugated polyethyleneglycol-modifiedpolyamidoamine dendrimer[J].The FASEB Journal,2007,21(4):1 117-1 125.