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Chemcial Industry and Engineering 2023, Vol. 40 Issue (1) :120-126    DOI: 10.13353/j.issn.1004.9533.20220365
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Polymorphs and crystal forms transformation of olaparib
ZHANG Jiao1, HUANG Xin2, HU Ruixin3, LI Hongming4
1. Sichun Kelun Pharmaceutical Co. Ltd., Chengdu 611138, China;
2. Tianjin University, Tianjin 300072, China;
3. College of Horticulture, Sichuan Agricultural University, Chengdu 611130, China;
4. Sinopharm Chuankang Pharmaceutical Co. Ltd., Chengdu 611730, China

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Abstract Olaparib is the first marketed poly-ADP-ribose polymerase inhibitor in the worldwide. In this paper, isostructural solvates phenomenon of olaparib were studied, it is found that isostructural solvates were determined to be isolated structure by single crystal of tetrahydrofuran solvate. Then, the thermodynamic stability relationship of anhydrous polymorph A and L was studied, and the possible reasons for the abnormal transformation from stable form to metastable form in organic solvents were analyzed. Furthermore, the effects of temperature and water ratio on the phase transition processes of Form A and hydrate Form H were investigated.
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ZHANG Jiao
HUANG Xin
HU Ruixin
LI Hongming
Keywordsolaparib   isostructural solvates   crystal form transformation     
Received 2022-07-25;
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ZHANG Jiao, HUANG Xin, HU Ruixin, LI Hongming.Polymorphs and crystal forms transformation of olaparib[J]  Chemcial Industry and Engineering, 2023,V40(1): 120-126
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