双负载抗生素亲水性聚氨酯泡沫的制备与表征

文章导读

摘要因细菌、异物和炎症等因素引起的慢性伤口会有过量的伤口渗出液流出，影响伤口周围健康皮肤，不利于伤口愈合。针对以上问题，我们开发了双负载亲、疏水性抗生素的亲水性聚氨酯泡沫作为慢性伤口的创面敷料。通过电子显微镜观察，泡沫的孔径均匀地分布在200~400 μm之间。聚氨酯泡沫中载入的药物对聚氨酯泡沫的力学性能略有影响，对吸液率、保水率没有影响，载入的亲水性药物能够快速释放，疏水性药物能够持续释放。载药聚氨酯泡沫对革兰氏阴性菌大肠杆菌和革兰氏阳性菌金黄色葡萄球菌均表现出优异的抗菌性能。同时，载药聚氨酯泡沫具有优异的生物相容性。因此，这种多功能聚氨酯泡沫适合作为慢性伤口敷料的候选材料。

	Service

	把本文推荐给朋友
	加入我的书架
	加入引用管理器
	Email Alert
	RSS
	作者相关文章
	高尚东
	陈尚良
	李双阳
	叶展鹏
	邓联东
	董岸杰

关键词：聚氨酯泡沫；药物释放；抗菌；敷料

Abstract： Chronic wounds caused by bacteria, foreign bodies, inflammation and other factors will have excessive wound exudate outflow, damaging the surrounding healthy skin, which is not conducive to wound healing. To solve the above problems, we prepared polyurethane foam containing hydrophilic and hydrophobic drugs as a wound dressing for chronic wounds. The pore size of the foam was uniform and distributed between 200—400 μm observed by SEM. The loading drugs had a slight effect on the mechanical properties of polyurethane foam and had little effect on the liquid absorption rate and water retention rate. The hydrophilic drug could be released rapidly, and hydrophobic drug could be released continuously. The drug-loaded polyurethane foam showed excellent antibacterial activity against gram-negative E. coli and gram-positive S. aureus. Meanwhile, polyurethane foams had excellent biocompatibility. Therefore, the multifunctional polyurethane foams are suitable as a candidate material for chronic wound dressing.

Keywords： polyurethane foam； drug release； antibacterial； dressing

Received 2021-01-11;

Fund:

Corresponding Authors: 邓联东,副教授,E-mail:dengliandong@tju.edu.cn Email: dengliandong@tju.edu.cn

引用本文:

高尚东, 陈尚良, 李双阳, 叶展鹏, 邓联东, 董岸杰.双负载抗生素亲水性聚氨酯泡沫的制备与表征[J]. 化学工业与工程, 2022,39(1): 11-18

GAO Shangdong, CHEN Shangliang, LI Shuangyang, YE Zhanpeng, DENG Liandong, DONG Anjie.Preparation and characterization of dual-antibiotic-loaded hydrophilic polyurethane foam[J]. Chemcial Industry and Engineering, 2022,39(1): 11-18

[1] SKÓRKOWSKA-TELICHOWSKA K, CZEMPLIK M, KULMA A, et al. The local treatment and available dressings designed for chronic wounds[J]. Journal of the American Academy of Dermatology, 2013, 68(4): e117-e126
[2] BOATENG J S, MATTHEWS K H, STEVENS H N E, et al. Wound healing dressings and drug delivery systems: A review[J]. Journal of Pharmaceutical Sciences, 2008, 97(8): 2892-2923
[3] EMING S A, MARTIN P, TOMIC-CANIC M. Wound repair and regeneration: Mechanisms, signaling, and translation[J]. Science Translational Medicine, 2014, doi: 10.1126/scitranslmed.3009337
[4] TAKEUCHI T, ITO M, YAMAGUCHI S, et al. Hydrocolloid dressing improves wound healing by increasing M2 macrophage polarization in mice with diabetes[J]. Nagoya Journal of Medical Science, 2020, 82(3): 487-498
[5] TAN W, ARULSELVAN P, NG S F, et al. Improvement of diabetic wound healing by topical application of Vicenin-2 hydrocolloid film on Sprague Dawley rats[J]. BMC Complementary and Alternative Medicine, 2019, doi: 10.1186/s12906-018-2427-y
[6] HIRANPATTANAKUL P, JONGJITPISSAMAI T, AUNGWEROJANAWIT S, et al. Fabrication of a chitin/chitosan hydrocolloid wound dressing and evaluation of its bioactive properties[J]. Research on Chemical Intermediates, 2018, 44(8): 4913-4928
[7] HAN L, WANG M, PRIETO-LÓPEZ L O, et al. Self-hydrophobization in a dynamic hydrogel for creating nonspecific repeatable underwater adhesion[J]. Advanced Functional Materials, 2020, doi: 10.1002/adfm.201907064
[8] KAUR P, GONDIL V S, CHHIBBER S. A novel wound dressing consisting of PVA-SA hybrid hydrogel membrane for topical delivery of bacteriophages and antibiotics[J]. International Journal of Pharmaceutics, 2019, doi: 10.1016/j.ijpharm.2019.118779
[9] PANG Q, ZHENG X, LUO Y, et al. A photo-cleavable polyprodrug-loaded wound dressing with UV-responsive antibacterial property[J]. Journal of Materials Chemistry B, 2017, 5(45): 8975-8982
[10] WANG Kang, HAO Yanli. Study on the capacity of calcium alginate sponge with or without silver nanoparticles[J]. Chemical Industry and Engineering, 2017, 34(3): 18-23(in Chinese) 王康, 郝艳丽. 海藻酸钙海绵及其载银后的性能研究[J]. 化学工业与工程, 2017, 34(3): 18-23
[11] ZHAO B, QIAN Y, QIAN X, et al. Fabrication and characterization of waterborne polyurethane/silver nanocomposite foams[J]. Polymer Composites, 2019, 40(4): 1492-1498
[12] PYUN D G, CHOI H J, YOON H S, et al. Polyurethane foam containing rhEGF as a dressing material for healing diabetic wounds: Synthesis, characterization, in vitro and in vivo studies[J]. Colloids and Surfaces B: Biointerfaces, 2015, 135: 699-706
[13] MORENA A G, STEFANOV I, IVANOVA K, et al. Antibacterial polyurethane foams with incorporated lignin-capped silver nanoparticles for chronic wound treatment[J]. Industrial & Engineering Chemistry Research, 2020, 59(10): 4504-4514
[14] LUNDIN J G, MCGANN C L, DANIELS G C, et al. Hemostatic Kaolin-polyurethane foam composites for multifunctional wound dressing applications[J]. Materials Science and Engineering: C, 2017, 79: 702-709
[15] BROEKEMA F I, OEVEREN W, SELTEN M H A, et al. In vivo hemostatic efficacy of polyurethane foam compared to collagen and gelatin[J]. Clinical Oral Investigations, 2013, 17(4): 1273-1278
[16] YANG S, LI X, LIU P, et al. Multifunctional chitosan/polycaprolactone nanofiber scaffolds with varied dual-drug release for wound-healing applications[J]. ACS Biomaterials Science & Engineering, 2020, 6(8): 4666-4676
[17] ZHAO W, ZHANG X, ZHANG R, et al. Self-assembled herbal medicine encapsulated by an oxidation-sensitive supramolecular hydrogel for chronic wound treatment[J]. ACS Applied Materials & Interfaces, 2020, 12(51): 56898-56907
[18] JALVANDI J, WHITE M, GAO Y, et al. Polyvinyl alcohol composite nanofibres containing conjugated levofloxacin-chitosan for controlled drug release[J]. Materials Science and Engineering: C, 2017, 73: 440-446
[19] JIANG H, FANG D, HSIAO B, et al. Preparation and characterization of ibuprofen-loaded poly(lactide-co-glycolide)/poly(ethylene glycol)-g-chitosan electrospun membranes[J]. Journal of Biomaterials Science, Polymer Edition, 2004, 15(3): 279-296
[20] WEI S, LIU X, ZHOU J, et al. Dual-crosslinked nanocomposite hydrogels based on quaternized chitosan and clindamycin-loaded hyperbranched nanoparticles for potential antibacterial applications[J]. International Journal of Biological Macromolecules, 2020, 155: 153-162
[21] WANG Deyuan, FENG Quan, WANG Yuxiao, et al. Preparation of cationic polyurethane foam carriers and their adsorption properties for activated sludge[J]. Acta Polymerica Sinica, 2012(6): 679-684(in Chinese) 王德源, 冯权, 王玉晓, 等. 阳离子型聚氨酯泡沫载体的制备及对活性污泥的吸附性能[J]. 高分子学报, 2012(6): 679-684