新型氟硼二吡咯纳米粒子荧光探针的合成与性能

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摘要为了解决氟硼荧类染料(BODIPY)在肿瘤诊断中吸收波长短、水溶性和生物相容性差的问题，设计开发了2种吸收波长达到近红外区的BODIPY分子，并通过与DSPE-PEG2000-MAL-RGD(PC-RGD)自组装形成具有良好水溶性和生物相容性的纳米粒子。研究了纳米粒子的荧光成像能力，结果表明：单取代分子3a和双取代分子3b的荧光发射波长分别达到了650和775 nm，且双取代分子3b表现出更大的斯托克斯位移，这是由于其具有更高的共轭程度。另外包裹后的纳米粒子表现出良好水溶性和生物相容性，为其作为肿瘤诊断的荧光探针提供了基础。

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	尹娟娟
	冯彤
	薛中博
	冯亚青
	孟舒献

关键词： BODIPY；纳米粒子；荧光探针；肿瘤诊断；脂质体

Abstract： In order to solve the problem of short absorption wavelength, poor water solubility and poor biocompatibility of Fluoroboron-fluorescent dyes (BODIPY) in tumor diagnosis, two BODIPY molecules with absorption wavelengths reaching the near-infrared region have been designed and synthesized, and they have been combined with DSPE-PEG2000-MAL-RGD (PC-RGD) to form nanoparticles with good water solubility and biocompatibility. Then the fluorescence imaging ability of nanoparticles was studied. The results showed that the fluorescence emission wavelengths of the mono-substituted molecule 3a and the di-substituted molecule 3b reached 650 and 775 nm, respectively. And di-substituted molecule 3b shows greater Stokes shift than 3a due to its higher degree of conjugation. Moreover, the encapsulated nanoparticles show good water solubility and biocompatibility, which provides a possibility as fluorescent probes for tumor diagnosis.

Keywords： fluoroboron-fluorescent dyes (BODIPY)； nanoparticles； fluorescent probe； tumor diagnosis； liposome

Received 2021-02-24;

Fund:国家自然科学基金资助项目（21676187）

Corresponding Authors: 孟舒献,副教授,E-mail:msxmail@tju.edu.cn Email: msxmail@tju.edu.cn

About author: 尹娟娟(1996-)，女，硕士研究生，现从事BODIPY光治疗应用的研究

引用本文:

尹娟娟, 冯彤, 薛中博, 冯亚青, 孟舒献.新型氟硼二吡咯纳米粒子荧光探针的合成与性能[J]. 化学工业与工程, 2022,39(1): 19-26

YIN Juanjuan, FENG Tong, XUE Zhongbo, FENG Yaqing, MENG Shuxian.Synthesis and properties of novel fluoroboron nanoparticle fluorescent probes[J]. Chemcial Industry and Engineering, 2022,39(1): 19-26

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