Prepration of N-Alkylated Chitosan Membrane and in Vitro Studies of pH-Sensitive Drug Delivery

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Abstract Glucose was oxidizes to generate a glucose dialdehyde and chitosan was hydrophobically modified with butyl bromide,octyl bromide and dexyl bromide.The results of IR and X-ray diffraction of chitosan derivatives confirm that the hydrogen bonds and crystallinity were weakened by the incorporation of pendant alkyl.The permeability coefficient P for model drug vitamin B 2 through oxidized glucose-crosslinked alkylated chitosan is determined in different pH media.The preliminary cytotoxicity assay indicates that oxidized glucose-crosslinked alkylate chitosan membrane is non-toxic in vitro .

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Received 2002-07-15; published 2002-07-15

Cite this article:

LI Fang, LIU Wen-guang, XUE Tao, YAO Kang-de .Prepration of N-Alkylated Chitosan Membrane and in Vitro Studies of pH-Sensitive Drug Delivery[J] Chemcial Industry and Engineering, 2002,V19(4): 281-285

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