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Chemcial Industry and Engineering 2005, Vol. 22 Issue (1) :67-69    DOI:
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Synthesis of Me-(3407) as an Anti-Ulcer Drug Candidate
CHANG Yue, SHANG Zhen-hua(College of Pharmaceuticals and Biotechnology,Tianjin University,Tianjin 300072, China)
(College of Pharmaceuticals and Biotechnology,Tianjin University,Tianjin 300072, China

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Abstract Synthesis of the anti-ulcer candidate drug,2-[(n-butoxycarbonylmethyl)sulfinyl]thiazolo-[5,4-b]pyridine,was analysed.The title compound was synthesized from niacinamide through five-step reaction according to the literature.The procedure of the last step was mended and the yield of the oxidation reaction was increased by optimizing the reaction conditions.
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Received 2005-01-15; published 2005-01-15
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CHANG Yue, SHANG Zhen-hua.Synthesis of Me-(3407) as an Anti-Ulcer Drug Candidate[J]  Chemcial Industry and Engineering, 2005,V22(1): 67-69
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