Preparation and Properties of Blend Microspheres of Polyvinyl Alcohol and Sodium Alginate
FENG Chao-Yang, CUI Yuan-Yuan, KANG Xiao-Mei, CHENG Li-Ping, ZHANG Zhi-Bin, LU Qun-
1.College of Life Science and Engineering,Southwest Jiaotong University,Chengdu 610031,China;2.College of Material Science and Engineering,Sichuan University,Chengdu 610064,China
Abstract Novel PVA-SA based microspheres,prepared by polymers solution blending method,were developed for the delivery of drug.The parameters such as the concentration of SA,PVA and CaCl2,mass ratio of PVA to SA and dry method were adjusted to improve the properties of blend microspheres.The water content,swelling rate,drug loading rate,entrapment efficiency and PTIR analysis were carried out to characterize the composite microspheres.The effects of the ratio of PVA to SA of blend microspheres on the sustained release behavior were also discussed.The results show that,when SA concentration is 6%,PVA concentration is 10% and CaCl2 concentration is 5%,and the mass ratio of PVA and SA is 1��3,blend microspheres with excellent properties can be prepared.The microspheres have high drug loading rate of 30.24%,entrapment efficient of 90.11%,good sustained release behavior and may be used as a special drug delivery system.
FENG Chao-Yang, CUI Yuan-Yuan, KANG Xiao-Mei, CHENG Li-Ping, ZHANG Zhi-Bin, LU Qun- .Preparation and Properties of Blend Microspheres of Polyvinyl Alcohol and Sodium Alginate[J] Chemcial Industry and Engineering, 2010,V27(5): 381-386
2010, Vol. 27 
