Application of Microextractor in Polymyxin B Extraction Process

Related Articles

Abstract A process for continuous extraction of polymyxin B was developed using miniaturization. By optimizing the key control parameters such as the micropore size of the disperser, the flow rate of the fluid in the microextractor channel, the number of microextractor stages in series and the solvent addition ratio of each stage in the multi-stage microextractor extraction process, good experimental results were achieved. The process has obvious advantages over the traditional stirred method extraction in terms of extraction rate, productivity and solvent consumption, with short operation time, good repeatability, stability and durability, and simple operation for continuous operation, which is suitable for the extraction of polymyxin B and other peptide antibiotics. It solves the problems of low extraction rate, long operation time, high solvent consumption and high COD emission of traditional stirred kettle extraction process. The miniaturization technology opens up new ideas for the realization of green production of peptide antibiotic API extraction.

	Service

	Email this article
	Add to my bookshelf
	Add to citation manager
	Email Alert
	RSS
	Articles by authors
	Cheng Yaofeng
	Zhang Lijuan
	Zhang Wei
	Ge Kunpeng
	Jü Jiaxue

Keywords： polymyxin B； microextractor； continuous extraction

Received 2020-12-23;

About author:

Cite this article:

Cheng Yaofeng, Zhang Lijuan, Zhang Wei, Ge Kunpeng, Jü Jiaxue.Application of Microextractor in Polymyxin B Extraction Process[J] Chemcial Industry and Engineering, 2021,V38(2): 55-60

[1] 钱梦茹. 多粘菌素B的作用机制研究新进展[J]. 甘肃医药, 2019, 38(5):397-399,421 Qian Mengru. Progress in the mechanism of action of polymyxin B[J]. Gansu Medical Journal, 2019, 38(5):397-399,421(in Chinese)
[2] 吴浣钱. 硫酸多粘菌素B菌种选育与发酵工艺的研究[J]. 山东工业技术, 2018,(18):14-16 Wu Huanqian. Study on the breeding and fermentation technology of polymyxin Bsulfate[J]. Shandong Industrial Technology, 2018,(18):14-16(in Chinese)
[3] 王崔岩, 郭月玲, 彭亮, 等. 多粘菌素B研究进展[J]. 煤炭与化工, 2014, 37(8):23-25,30 Wang Cuiyan, Guo Yueling, Peng Liang, et al. Research progress of polymyxin B[J]. Coal and Chemical Industry, 2014, 37(8):23-25,30(in Chinese)
[4] 常晓菲, 王宏, 王静, 等. 硫酸多粘菌素B提取工艺的研究进展[J]. 北方药学, 2011, 8(10):13-13
[5] 褚良银, 汪伟, 巨晓洁, 等. 微流控法构建微尺度相界面及制备新型功能材料研究进展[J]. 化工进展, 2014, 33(9):2229-2234 Chu Liangyin, Wang Wei, Ju Xiaojie, et al. Progress of construction of micro-scale phase interfaces and preparation of novel functional materials with microfluidics[J]. Chemical Industry and Engineering Progress, 2014, 33(9):2229-2234(in Chinese)
[6] 刘兆利, 张鹏飞. 微反应器在化学化工领域中的应用[J]. 化工进展, 2016, 35(1):10-17 Liu Zhaoli, Zhang Pengfei. Applications of microreactor in chemistry and chemical engineering[J]. Chemical Industry and Engineering Progress, 2016, 35(1):10-17(in Chinese)
[7] 赵述芳, 白琳, 付宇航, 等. 液滴流微反应器的基础研究及其应用[J]. 化工进展, 2015, 34(3):593-607, 616 Zhao Shufang, Bai Lin, Fu Yuhang, et al. Fundamental research and applications of droplet-based microreactor[J]. Chemical Industry and Engineering Progress, 2015, 34(3):593-607, 616(in Chinese)
[8] Jovanovi? J, Rebrov E V, Nijhuis T A, et al. Liquid-liquid flow in a capillary microreactor:hydrodynamic flow patterns and extraction performance[J]. Industrial & Engineering Chemistry Research, 2012, 51(2):1015-1026
[9] 凌芳, 顾小焱, 柯德宏, 等. 微通道反应器的发展研究进展[J]. 上海化工, 2017, 42(4):35-38 Ling Fang, Gu Xiaoyan, Ke Dehong, et al. Development of micro-channel reactor[J]. Shanghai Chemical Industry, 2017, 42(4):35-38(in Chinese)
[10] 李韡, 张昱, 孟昊, 等. 微通道中液-液萃取传质特性的研究[J]. 化学工业与工程, 2013, 30(4):36-41 Li Wei, Zhang Yu, Meng Hao, et al. Mass transfer characteristics of liquid-liquid extraction in microchannel[J]. Chemical Industry and Engineering, 2013, 30(4):36-41(in Chinese)
[11] 荀涛, 蔡旺锋, 张旭斌. 微通道中气-液-液三相流流型及传质研究[J]. 化学工业与工程, 2017, 34(6):81-87 Xun Tao, Cai Wangfeng, Zhang Xubin. The flow pattern and mass transfer of gas-liquid-liquid three phase flow in microchannel[J]. Chemical Industry and Engineering, 2017, 34(6):81-87(in Chinese)
[12] 陈娅君, 龙威, 何永清, 等. 液-液多相流微萃取的数值模拟和实验分析[J]. 化工进展, 2019, 38(5):2085-2092 Chen Yajun, Long Wei, He Yongqing, et al. Numerical simulation and experimental analysis of liquid-liquid multiphase microextraction[J]. Chemical Industry and Engineering Progress, 2019, 38(5):2085-2092(in Chinese)
[13] 周月, 潘美园, 陈桂子, 等. 金属套管式微通道气液传质特性研究[J]. 北京化工大学学报:自然科学版, 2013, 40(3):12-16 Zhou Yue, Pan Meiyuan, Chen Guizi, et al. Gas-liquid mass transfer performance in a metal tube-in-tube microchannel[J]. Journal of Beijing University of Chemical Technology:Natural Science Edition, 2013, 40(3):12-16(in Chinese)
[14] 张莹. 微通道内液-液传质与相分离模拟研究[D]. 天津:天津大学, 2015 Zhang Ying. Numerical study of liquid-liquid mass transfer and phase separation in microchannel[D]. Tianjin:Tianjin University, 2015(in Chinese)
[15] 刘妍, 张宸, 吴可君, 等. 微通道内离子液体萃取硫酸铵水溶液中丁酮肟的研究[J]. 高校化学工程学报, 2017, 31(3):530-538 Liu Yan, Zhang Chen, Wu Kejun, et al. Microchannel extraction of butanone oxime from aqueous ammonium sulfate solution using ionic liquids[J]. Journal of Chemical Engineering of Chinese Universities, 2017, 31(3):530-538(in Chinese)
[16] 李硕, 李宗祥, 刘一哲, 等. 多级错流溶剂萃取分离正丁醇-水混合物[J]. 北京化工大学学报:自然科学版, 2015, 42(2):25-29 Li Shuo, Li Zongxiang, Liu Yizhe, et al. Separation of n-butanol-water mixtures by multi-stage cross-flow solvent extraction[J]. Journal of Beijing University of Chemical Technology:Natural Science Edition, 2015, 42(2):25-29(in Chinese)