Facile Preparation of Hollow Mesoporous Silica Nanoparticles Coated with pH-Sensitive Polymer

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Abstract

Trimethoxysilyl-propyl-trithiocarbonyl-benzyl ester(BTPT), which is one of the silicone-based RAFT agents, was grafted onto the surface of silica nanospheres. Using the reversible addition-fragmentation chain transfer polymerization, silica nanospheres modified with the pH-and temperature-sensitive polyelectrolyte poly(N, N-dimethylaminoethyl methacrylate) (PDMAEMA) were prepared. Then silica nanospheres grafted with PDMAEMA were transformed to the hollow mesoporous structure by surface-protected etching strategy using ammonia at ambient temperature, thereby obtained the hollow mesoporous silica nanospheres modified with the PDMAEMA (HMS@PDMAEMA). The resultant composite nanoparticles with pH-and temperature-sensitive polymer shell and HMS core were characterized by a variety of techniques such as ¹HNMR, FTIR, GPC and TEM, etc. The pH-sensitive behavior was tested by nano-size and zeta potential analyzer. We envision that the HMS@PDMAEMA should have potential applications in controlled release of anticancer drug and gene delivery.

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	Articles by authors
	Zhong Qing
	Zhang Jianhua
	Guo Ruiwei

Keywords： hollow mesoporous silica nanoparticles； surface modification； polymer； pH-sensitive behavior

Received 2015-04-21;

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Cite this article:

Zhong Qing, Zhang Jianhua, Guo Ruiwei.Facile Preparation of Hollow Mesoporous Silica Nanoparticles Coated with pH-Sensitive Polymer[J] Chemcial Industry and Engineering, 2017,V34(2): 50-54

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