Synthesis and Properties Study of the Near-Infrared Fluorescence Molecular Probe Glycine-BDDIPY

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Abstract

In this paper, we used a BDDIPY with near-infrared fluorescent properties as imaging group to produce a new type of near infrared fluorescence molecular probe for detecting tumor cells. Firstly, BOD was used as the starting materials, and then introduced N-phenyl iminodibenzyl with strong electron-donating ability into the BDDIPY dye through condensation reaction. Then we gained the glycine-BDDIPY compound which has the near-infrared fluorescence spectrum. Next, with N-hydroxy succinimide as an activator,glycine methyl ester was introduced into the BDDIPY. Finally we get a biocompatible glycine-BDDIPY molecular fluorescent probe which having affinity with tumors. All the intermediates and target products were characterized by ¹H NMR and MALDI-TOF. These BODIPYs were tested to characterize their optical and biological properties. Experimental results showed that the fluorescence emission wavelength of glycine-BDDIPY is longer than 700 nm. And it had a good affinity with lung cancer cells at about 23.65. This indicates that glycine-BDDIPY has a good application prospect for detecting tumor cells.

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	Articles by authors
	Dong Xue
	Zhang Jie
	Wang Kunpeng
	Fang Shuo
	Liu Yang
	Meng Shuxian
	Feng Yaqing

Keywords： BODIPY； glycine； tumor imaging； fluorescence molecular probe

Received 2015-04-07;

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Dong Xue, Zhang Jie, Wang Kunpeng, Fang Shuo, Liu Yang, Meng Shuxian, Feng Yaqing.Synthesis and Properties Study of the Near-Infrared Fluorescence Molecular Probe Glycine-BDDIPY[J] Chemcial Industry and Engineering, 2017,V34(2): 27-34

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