[1] Sierra P G, Sierra M G. Ascomycin and FK506:Pharmacology and therapeutic potential as anticonvulsants and neuroprotectants[J]. CNS Neuroscience & Therapeutics, 2008, 14:36-46
[2] 齐海山. 子囊霉素高产菌株选育及本征动力学研究[D]. 天津:天津大学, 2012 Qi Haishan. Study on the breeding of high-yielding strain and intrinsic kinetics for ascomycin[D]. Tianjin:Tianjin University, 2012(in Chinese)
[3] 杨文革, 陈林, 雷子瑜, 等. 发酵法生产子囊霉素的研究进展[J]. 化工进展, 2010, 29(7):1309-1313 Yang Wenge, Chen Lin, Lei Ziyu, et al. Progress in production of ascomycin via fermentation[J]. Chemical Industry and Engineering Progress, 2010, 29(7):1309-1313(in Chinese)
[4] 吴绍熙, 郭宁如. 大环内酯类免疫抑制剂研究进展[J].中国新药杂志, 2001, 10(8):566-569 Wu Shaoxi, Guo Ningru. Progress in macrolide immunosuppressant[J]. Chinese New Drugs Journal, 2001, 10(8):566-569(in Chinese)
[5] Wu K, Chung L, Pevill W P, et al. The FK520 gene cluster of Streptomyces hygroscopicus var. ascomyceticus (ATCC 14891) contains genes for biosynthesis of unusual polyketide extender units[J]. Gene, 2000, 251:81-90
[6] Sang J M, Young J Y, Yeon H B. Roles of fkbN in Positive regulation and tcs7 in negative regulation of FK506 biosynthesis in Streptomyces sp. Strain KCTC 11604BP[J]. Applied and Environmental Microbiology, 2012, 78:2249-2255
[7] Carlos B, Miriam M C. Trends in the biosynthesis and production of the immunosuppressant tacrolimus (FK506)[J]. Applied Microbiology and Biotechnology, 2014, 98(2):497-507
[8] Gatto G J, Mcloughlin S M, Wash C T, et al. Elucidating the substrate specificity and condensation domain activity of FkbP, the FK520 pipecolate-incorporating enzyme[J]. Biochemistry, 2005, 44(16):5993-6002
[9] Dušan G, Marko B, Vasilka M, et al. FK506 biosynthesis is regulated by two positive regulator elements in Streptomyces tsukubaensis[J]. BMC Microbiology, 2012, 12:238-252
[10] 陈单丹, 岑沛霖, 刘文, 等. 大环内酯类免疫抑制剂他克莫司的生物合成机制研究进展[J]. 有机化学, 2013, 33:1254-1262 Chen Dandan, Cen Peilin, Liu Wen, et al. Progress in studing the biosynthetic mechanicm of the macrolide immunosuppressant tacrolimus[J]. Chinesse Journal of Organic Chemistry, 2013, 33:1254-1262(in Chinese)
[11] Paiva N L, Roberts M F, Demain A L. The cyclohexane moiety of rapamycin id derived from shikimic acid in Streptomyces-hygroscopicus[J]. Journal of Industrial Microbiology & Biotechnology, 1993, 12:423-428
[12] Andexer J N, Kendrew S G, Mohammad N E A, et al. Biosynthesis of the immunosuppressants FK506, FK520, and rapamycin involves a previously undescribed family of enzymes acting on chorismate[J]. Proceedings of the National Academy of Sciences, 2011, 108(12):4776-4781
[13] Lowden P A S, Bohm C A, Staunton J, et al. The nature of the stater unite for the rapamycin polyketide synthase[J]. Angew Angewandte Chemie International Edition, 1996, 35:2249-2251
[14] Carroll B J, Moss S J, Floss H G. Identification of a set of genes involved in the formation of the substrate for the incorporation of the unusual "glycolate" chain extension unit inansamitocin biosynthesis[J].Journal of the American Chemical Society, 2002, 124:4176-4177
[15] Chan Y A, Boyne M T, Podevel A M, et al. Hydroxymalonylacyl carrier protein (ACP) and aminomalonyl-ACP are two additional type I polyketide synthase extender units[J]. Proceedings of the National Academy of Sciences, 2006, 103(39):14349-14354
[16] Paiva N L, Demain A L, Roberts M F. The immediate precursor of the nitrogen-containing ring of rapamycin is free pipecolic acid[J]. Enzyme and Microbial Technology, 1993, 15:581-585
[17] Schwecke T, Aparicio J F, Molnar I, et al. The biosynthetic gene cluster for the polyketide immunosuppressant rapamycin[J]. Proc Natl Acad Sci USA, 1995, 92:7839-7843
[18] Gatto G J, Boyne M T, Wash C T,et al. Biosynthesis of pipecolic acid by RapL, a lysine cyclodeaminase encoded in the rapamycin gene cluster[J]. Journal of the American Chemical Society, 2006, 128(11):3838-3847
[19] Parveen K, Kumar S S, Kumar M H,et al. An improved fermentation process for preparing ascomycin:WO, 029082[P]. 2007-03-15
[20] 穆云龙, 余旭亚, 孟庆雄. 莽草酸对子囊霉素生物合成的影响[J]. 中国抗生素杂志, 2008, 6(23):3-4 Mu Yunlong, Yu Xuya, Meng Qingxiong. Effect of shikimic acid on the ascomycin biosynthesis[J]. Chinese Journal of Antibiotics, 2008, 6(23):3-4(in Chinese)
[21] Qi H, Xin X, Wen J, et al. Higher-Lever production of ascomycin(FK520) by Streptomyces hygroscopicus var. ascomyceticus irradiated by femtosecond laser[J]. Biotechnology and Bioengineering, 2012, 17:770-779
[22] Qi H, Zhao S, Wen J, et al. Analysis of ascomycin production enhanced by shikimic acid resistance and addition in Streptomyces hygroscopicus var. ascomyceticus[J]. Biochemical Engineering Journal, 2014, 82:124-133
[23] Qi H, Zhao S, Wen J, et al. Enhancement of ascomycin production in Streptomyces hygroscopicus var. ascomyceticus by combining resin HP20 addition and metabolic profiling analysis[J]. Journal of Industrial Microbiology, 2014, 41(9):1365-1374