Synthesis of Pyraclostrobin

化学工业与工程

Chemcial Industry and Engineering

2016, Vol. 33

Issue (1) :45-50 DOI: 10.13353/j.issn.1004.9533.20131201

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Synthesis of Pyraclostrobin

Li Qing, Li Wei, Liu Dongzhi, Zhou Xueqin

School of Chemical Engineering and technology, Tianjin University, Tianjin 300072

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Abstract

Pyraclostrobin was synthesized by reaction of methyl N-methoxyl-N-2-bromine toluene carbamate with 1-(4-chlorophenyl)-3-hydroxypyrazole, methyl N-methoxyl-N-2-bromine toluene carbamate was prepared from o-nitrotoluene by reduction, acylation, methylation, and bromination four steps. Under the optimal condition, the purity was 98.4%(LC), and the total yield was 56.7% based on o-nitrotoluene. The structure of the prepared product was confirmed by ¹H-NMR and MS. The process exhibites mild reaction conditions and high yield, and is suitable for industrial production.

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	Li Qing
	Li Wei
	Liu Dongzhi
	Zhou Xueqin

Keywords： pyraclostrobin； o-nitrotoluene； 1-(4-chlorophenyl)-3-hydroxypyrazole； synthesis

Received 2013-12-04;

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Li Qing, Li Wei, Liu Dongzhi, Zhou Xueqin.Synthesis of Pyraclostrobin[J] Chemcial Industry and Engineering, 2016,V33(1): 45-50

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