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Chemcial Industry and Engineering 2015, Vol. 32 Issue (6) :69-73    DOI: 10.13353/j.issn.1004.9533.20141043
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Repairing Effect of Chitosan on Oxidative Damaged HepG2 Cells
Xiao Mei1, Wang Li2, Liu Qianwen2, Gao Wenyuan1
1. School of Pharmaceutical Science and Technology, Tianjin University, Tianjin 300072, China;
2. School of Materials Science and Engineering, Tianjin University, Tianjin 300072, China

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Abstract 

In vitro cellular experiment was made to explore the repairing effect of different doses of chitosan on oxidative damaged HepG2 cells. Compared with ascorbic acid, cell morphology and viability, activity of SOD and GSH-Px and level of MDA were the evaluation indexes. Results showed that chitosan could significantly improve the level of SOD and GSH-Px activity, and decrease the content of MDA. Therefore chitosan can repair the morphology and viability of oxidative damaged HepG2 cell. The repairing effect of chitosan on oxidative damaged HepG2 cells was better than that of ascorbic acid.

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Xiao Mei
Wang Li
Liu Qianwen
Gao Wenyuan
Keywordschitosan;   HepG2 cells;   oxidative damage;   repairing     
Received 2014-12-31;
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Xiao Mei, Wang Li, Liu Qianwen, Gao Wenyuan.Repairing Effect of Chitosan on Oxidative Damaged HepG2 Cells[J]  Chemcial Industry and Engineering, 2015,V32(6): 69-73
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